Structure of a bacterial RNA polymerase holoenzyme open promoter 2 complex 3 4

The Rockefeller University, Laboratory for Molecular Biophysics, 1230 York Avenue, New York, 7 NY 10065, USA. 8 Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University 9 School of Medicine, St. Louis, MO 63104, USA. 10 3 Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53705, USA. 11 4 Department of Bacteriology, University of Wisconsin-Madison, Madison, WI 53705, USA. 12 13 14 These authors contributed equally to this work. 15 Correspondence to: E-mail: [email protected]. Phone: 212-327-7479. 16